Week 2 brings Saints vs 49ers with Vegas at SF -3 and a 40.5 total, while 65% of public money backs New Orleans. Start Alvin Kamara for volume and dual-threat usage, and lean into 49ers stars in a favorable matchup. Fade the shaky Saints passing game and kicker Blake Grupe after a 40-yard miss. Expect a tight, lower-scoring game in a dome with clear lineup paths.
Tampa Bay edged Atlanta 23-20 on the road to open the 2025 season, winning a tight NFC South game without star tackle Tristan Wirfs. Bucky Irving’s yards-after-catch skills and a mobile quarterback powered a balanced Bucs attack. Falcons QB Michael Penix Jr. led a late push that fell short. Both teams battled offensive line absences, hinting at a tense divisional race ahead.